Roblog

Over at Astral Codex Ten, Scott Alexander digs into the science behind anti-obesity drug Ozempic, and the subsequent array of secondary effects that have emerged in the scientific literature.

“GLP-1 receptor agonist medications like Ozempic are already FDA-approved to treat diabetes and obesity. But an increasing body of research finds they’re also effective against stroke, heart disease, kidney disease, Parkinson’s, Alzheimer’s, alcoholism, and drug addiction.

“There’s a pattern in fake scammy alternative medicine. People get excited about some new herb. They invent a laundry list of effects: it improves heart health, softens menopause, increases energy, deepens sleep, clears up your skin. This is how you know it’s a fraud. Real medicine works by mimicking natural biochemical signals. Why would you have a signal for ‘have low energy, bad sleep, nasty menopause, poor heart health, and ugly skin’? Why would all the herb’s side effects be other good things? Real medications usually shift a system along a tradeoff curve; if they hit more than one system, the extras usually just produce side effects. If you’re lucky, you can pick out a subset of patients for whom the intended effect is more beneficial than the side effects are bad. That’s how real medicine works.

“But GLP-1 drugs are starting to feel more like the magic herb. Why?”